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Stem cell therapy is a new form of treatment that has begun to attract the attention of doctors and patients, and is considered under the title of "regenerative medicine applications". Developing medical technological opportunities open new horizons for us in obtaining and applying stem cells (SVF). Cell culture, that is, reproduction of stem cells, is subject to the permission of the Ministry of Health. However, as I said, developing technological events lead to the emergence of new treatment areas in Medicine. Stem cell therapy is actually a treatment that has been practiced since the 1960s. This treatment, known as bone marrow transplantation, was a method that started to be applied for leukemia patients and its positive results were accepted by everyone.
Stem cells, which are prepared and given to the body, not only activate the healing power of the body, but also cause the release of chemicals that attract and take other stem cells to damaged areas. Continue reading our article for all the features about stem cells.
In a sense, it is an application that triggers the body's own healing mechanisms. What should be known in stem cell treatments is that different stem cell types come from different parts of the body and provide different functions. Scientists think that stem cells have specific and limited abilities, and they are investigating the different roles that tissue-specific stem cells can play in the healing process.
Stem cells, in a word, are “undifferentiated cells. This means that, unlike other cells in the body, it has the potential to transform into a wide variety of other cells. They carry with them the ability to repair and restore internal systems. So, in theory, it could help stem cells repair tissues, muscles, blood, bones and organs, aid growth and even replace missing parts. Tissue-specific stem cells have the ability to produce other cell types of the tissue they live in, if they are not interfered with in the laboratory. It is important where the stem cells are obtained from, where they are placed for what purpose and where they are placed. Otherwise, irrelevant cells may be injected into irrelevant places, causing undesirable results.
They are groups of cells in our own body that have not become organs.
Where is it located?
Stem cells are found in almost every tissue in our body.
What is its Importance in Treatment?
They initiate the process of repair and regeneration in tissues that have been degenerated and destroyed.
The cells existing in the person himself do not harm when applied in the treatment. This has been proven by scientific studies.
These applications, which require a special laboratory setup, are applied in a few developed centers in the world. However, we do not make specific applications to cancer. If the patient is in remission, that is, after chemotherapy or radiotherapy treatments, if the patient has recovered and this period has exceeded 5 years, we apply stem cell therapy, especially for the joints, in these cases.
We most often use stem cells taken from belly fat and bone marrow in the treatment.
The application is a 1-day procedure. For example, the patient who arrives at 9.00 in the morning becomes ready for the application at 15.00 in the afternoon. After the application, patients can go home on foot.
Patients can have a light breakfast in the morning, after which only local anesthesia is applied and approximately one glass of oil is aspirated and removed. If stem cells are to be prepared from the bone marrow, a glass of blood and bone marrow is taken from the pelvis in the hip region. And it is delivered to the lab. After a process of approximately 4-5 hours in the laboratory, stem cells are collected, concentrated and organ-specific awakening is performed. Stem cells are inactive cells, they need to be awakened and activated according to the target organ. There is a separate awakening procedure for the joints and a separate awakening procedure for the nerve tissues.
It is not the same. In fact, a fluid called SVF (stromal Vascular Fraction), which we call stem cells, is obtained. Injection of substances that are extracted by centrifuging only fat from the belly is presented as stem cells in the market. One of the tricks of the work is that the prepared stem cells should be given from the blood. Unawakened stem cells only mean fat transfer and its effectiveness is not sufficient.
The best results in stem cell treatments, which are accepted as prosthetic-sparing treatment, are obtained in cases of joint degeneration. Cartilage abrasions and calcifications in the knee and hip joints benefit greatly from this treatment, and nowadays, stem cell treatments are offered as an alternative to knee and hip prostheses in the west. In this context, if we talk about the experience of our team. Since 2009, 85% of the patients have been saved from prosthetic surgery with stem cell therapy (evoked SVF) applied to around 650 patients with joint degeneration who need a prosthesis or are told that a prosthesis will save you now. A single application is sufficient. Rarely, a second application can be made with a special application in the area where these stem cells are injected. With the second application, most of the patients recover.
Mesenchymal stem cells obtained from the bone marrow are beneficial in both children and adults in immune system diseases called Multiple Sclerosis. In the world, stem cell therapy is about to take priority in MS patients. It is reported that the disease is stopped for 1-2 years after the treatment and some clinical improvements are achieved.
In these cases, as high as 75%, there is improvement in motor function, that is, in movements. It has been reported that there is an increase in intelligence activities and some improvements in speech disorders. In these patients, recovery begins 1 month after stem cell application and takes shape within 6 months.
Three months after stem cell treatment in autistic children, an increase in learning capacity, an increase in verbal and non-verbal communication, and an improvement in social behavior of around 60% are observed.
Approximately 9 out of 15 patients benefit from this treatment. The recovery process after the application develops slowly and takes up to 6 months. In the name of recovery, these patients can become self-sufficient in daily activities.
It is especially useful in heart failure. Even in patients who have had myocardial infarction, when stem cells are injected into the coronary vessels during angiography or by the angio method, the damaged areas heal in most patients.
When foot vascular disorders, which are more common in smokers, are severe, the toes are surgically amputated. Sometimes the feet can be cut up to the knee. When stem cell therapy is given from the blood and around the vessels, these patients can recover.
Spinal cord injuries most commonly occur as a result of spinal cord fractures crushing or cutting the spinal cord as a result of motor vehicle accidents, falls, acts of violence or sports accidents. Damage to the spine usually causes impairment or loss in muscle movements, muscle control, senses, and body control.
Scientific and technological developments open new horizons for us. Many organizations and clinics are currently studying the safety and effectiveness of stem cells in the treatment of pain. Preliminary data in pain management are promising. For the Stem Cell application in Pain Treatment, I would like to give brief information about the painful conditions that have been scientifically researched and which we also apply. Good results have been obtained in neuropathic pain, Degenerative Disc Disease (low back pain), worn, calcified knee, hip and other joint arthrosis.
Because of the ability of stem cells to regenerate and regenerate, their application in pain management is a logical step. As an Algology specialist, I am happy to see that the diseases that medicine can only solve with surgery are now being solved one by one with non-surgical methods and I am happy to convey this information to you. The impossibilities of yesterday become the possibilities of today. In the treatment of pain, especially worn joints, which are the knees and hips, are treated to fix the cartilage structures in the joints, relieve pain and remove the fear of prosthetics, on the other hand, repair of degenerated discs between the spines, repair of damaged nerves, neuropathic pain. Regenerative applications for the elimination of it have started to become current. We use mesenchymal stem cells in pain treatment. To obtain mesenchymal stem cells, the most numerically dense regions of the cells are selected. These are bone marrow and adipose tissue.
These cells contribute to the healing process with the substances they secrete (hormone, cytokine, exosome). These secretions; They cause an increase in vascularity in the damaged tissue, stimulate the stem cells in that area, enable them to participate in the repair and ensure that the immune system works more effectively.
Direct application to the damaged joint, intravenous systemic application, specific systemic application targeting the brain tissue.
The procedure performed in this treatment is not only stem cell transplantation, but also the procedure of bringing these cells from the sleep phase to the awake working phase. In addition, if stem cells are to be injected into the joint, the "autologous fat graft" specially prepared from the patient's own fat tissue is injected into the joint. Another point is that individual and disease-specific modifications are made with stem cells prepared by considering the special conditions of each patient.
As a result, stem cell applications are among the treatments that come to the rescue of patients who have lost hope. It is our greatest wish that these treatments become widespread, their costs are reduced, and they become widely applied to those in need with state facilities.
In recent years, our country has proven its effectiveness in a wide range of health applications, especially in the Middle East, Europe and Asia. As a result, Turkey is a country that has come to the forefront with its advanced physician skills that have completed its infrastructure in terms of space, team and equipment. It has to add a new one to general health applications and to introduce formulas that will further pave the way for daily stem cell applications. We have to take measures that will compete with the American and European countries, such as Israel, Ukraine and India, that keep the indications and not given to the public, and therefore provide serious economic input, that will prevent our people from going there and encourage them to receive these treatments in our country.
